Significant attention and funding have been directed toward addressing the national opioid epidemic in recent years, with a focus on its devastating impact on Tribal communities. These funding efforts aim to reduce opioid-related deaths through initiatives such as strategic planning, prevention and education programs, medication-assisted therapy, diverse treatment approaches, workforce development, and community recovery support. The Tribal Opioid Response Resource Toolkit offers a comprehensive collection of materials, tools, resources, and links designed to assist Tribes in combating the opioid crisis and promoting healing within their communities.